Trends and Prospects in Inflammation Resolution in Acute Lung Injury and Acute Respiratory Distress Syndrome: A Bibliometric Quantitative and Visualization Analysis.

BACKGROUND

Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are common and critical pulmonary conditions involving numerous inflammatory factors and oxidative stress responses. Inflammatory responses and oxidative stress are closely related to the development of ALI/ARDS and form an important theoretical basis for treatment and drug development. Although there has been extensive research on the resolution of inflammation in ALI/ARDS, no systematic bibliometric analysis has been conducted in this field.

METHODS

The researchers used bibliometrics to search the Web of Science Core Collection (WOSCC) database for research literature on the resolution of inflammation in ALI/ARDS from 2005 to 2024. Visualization mapping analysis was performed using tools such as CiteSpace and VOSviewer to analyze authors, research institutions, countries, journals, cocited literature, and keywords.

RESULTS

A total of 375 articles were included. The research showed an upward trend, with the highest number of publications in 2022. The United States took the leading position in this field, followed by China. JIN SW had the highest number of publications, while D'Alessio FR had the highest citation count. Harvard University had the highest intermediary centrality, the American Journal of Physiology-Lung Cellular and Molecular Physiology published the most articles, and the American Journal of Respiratory and Critical Care Medicine had the highest impact factor. Resolvin D1 (RvD1) and Resolvin E1 (RvE1) played a key role in the resolution of inflammation. Drug delivery systems (DDSs), such as black phosphorus nanosheets (BPNSs) and liposomes, could efficiently deliver these mediators to enhance therapeutic effects and reduce side effects.

CONCLUSION

Over the past 20 years, interest in the resolution of inflammation in ALI/ARDS has grown. The United States has dominated research in this area. The study of RvD1 and RvE1 has become a hot topic, and the development of DDSs has provided new strategies for clinical treatment.