Journal of affective disorders · 2025
Heterogeneity of emotional responses to interpersonal stress in borderline personality disorder.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ducasse Déborah, Malestroit Manon, Bourret Julie, Brand-Arpon Véronique, Lafrancesca Audrey, Courtet Philippe, Olié Emilie
Аннотация
BACKGROUND: Borderline Personality Disorder (BPD) is characterized by heightened vulnerability to interpersonal stressors, particularly rejection and abandonment. Emotional dysregulation, especially shame and anger, is a hallmark of BPD, yet variability in emotional response profiles and their biological correlates remain insufficiently understood.
METHODS: We examined emotional and biological responses to an ecological interpersonal stress task replicating real-life abandonment scenarios in 58 female patients with BPD and 57 age-matched healthy controls. Emotional states (shame, anger, sadness, guilt, fear) were assessed at baseline, immediately post-task, and at 5, 15, and 40 min using Likert scales. Blood copeptin levels were measured at the same time points as a biomarker of vasopressinergic stress responses.
RESULTS: Both groups showed significant increases in shame, anger, sadness, and guilt immediately after the task (all p < 0.05). Healthy controls returned to baseline within 40 min, whereas patients with BPD exhibited sustained elevations in shame, anger, and sadness (all p < 0.05). No significant changes in copeptin levels were observed in either group, questioning its utility as a biomarker of acute interpersonal stress. Cluster analysis identified two subgroups within the BPD sample: one characterized by severe dysregulation, high shame-proneness, and an 83 % prevalence of suicide attempts (N = 30), and another with milder reactivity and faster recovery (N = 24).
CONCLUSIONS: Findings highlight heterogeneity of emotional responses to abandonment in BPD and underscore the clinical need for subgroup-tailored interventions. Results also challenge the relevance of copeptin as a biomarker of acute interpersonal stress in this population.
METHODS: We examined emotional and biological responses to an ecological interpersonal stress task replicating real-life abandonment scenarios in 58 female patients with BPD and 57 age-matched healthy controls. Emotional states (shame, anger, sadness, guilt, fear) were assessed at baseline, immediately post-task, and at 5, 15, and 40 min using Likert scales. Blood copeptin levels were measured at the same time points as a biomarker of vasopressinergic stress responses.
RESULTS: Both groups showed significant increases in shame, anger, sadness, and guilt immediately after the task (all p < 0.05). Healthy controls returned to baseline within 40 min, whereas patients with BPD exhibited sustained elevations in shame, anger, and sadness (all p < 0.05). No significant changes in copeptin levels were observed in either group, questioning its utility as a biomarker of acute interpersonal stress. Cluster analysis identified two subgroups within the BPD sample: one characterized by severe dysregulation, high shame-proneness, and an 83 % prevalence of suicide attempts (N = 30), and another with milder reactivity and faster recovery (N = 24).
CONCLUSIONS: Findings highlight heterogeneity of emotional responses to abandonment in BPD and underscore the clinical need for subgroup-tailored interventions. Results also challenge the relevance of copeptin as a biomarker of acute interpersonal stress in this population.