International journal of psychiatry in medicine · 2006
Role of dissociation in "false drug allergy".
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Rodriguez-Cano Teresa, Beato-Fernandez Luis, Galindo-Bonilla Pedro
Аннотация
OBJECTIVE: The aim of the present study was to analyze the influence of dissociation on the "false allergy" phenomenon.
METHOD: Fifty-five individuals (11 males and 44 females) who consecutively presented for the study of their suspected drug allergy were assessed.
RESULTS: After the challenge test, false allergy was found in 39.3% and placebo positive response in 12.5% of the patients. Seven patients (12.5%) scored above the cut-off point of 20 on the Dissociative Experiences Scale (DES), and 5 out of this group (71.4%) fit in the "false allergy" group. Pathological scores on the DES were associated with the diagnosis of "false allergy" (OR = 9.583, 95% CI = 1.002, 91.621). The effect of age, gender, and other psychopathological variables was controlled.
CONCLUSIONS: High levels of dissociation might predispose to false drug allergy, which could complicate pharmacological treatment and therefore increase the patient's complaints and demands for medical attention.
METHOD: Fifty-five individuals (11 males and 44 females) who consecutively presented for the study of their suspected drug allergy were assessed.
RESULTS: After the challenge test, false allergy was found in 39.3% and placebo positive response in 12.5% of the patients. Seven patients (12.5%) scored above the cut-off point of 20 on the Dissociative Experiences Scale (DES), and 5 out of this group (71.4%) fit in the "false allergy" group. Pathological scores on the DES were associated with the diagnosis of "false allergy" (OR = 9.583, 95% CI = 1.002, 91.621). The effect of age, gender, and other psychopathological variables was controlled.
CONCLUSIONS: High levels of dissociation might predispose to false drug allergy, which could complicate pharmacological treatment and therefore increase the patient's complaints and demands for medical attention.