Multiple sclerosis and related disorders · 2018
Retrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Konuskan Bahadır, Yildirim Mirac, Gocmen Rahsan, Okur Tuncay Derya, Polat Ipek, Kilic Huseyin, Saltik Sema, Ozturk Zeynep, Gucuyener Kivilcim, Altunbasak Sakir, Celik Tamer, Kose Gulsen, Yilmaz Arzu, Komur Mustafa, Kayilioglu Hulya, Anlar Banu
Аннотация
BACKGROUND: Knowledge has been expanding on myelin oligodendrocyte glycoprotein (MOG) antibody-associated central nervous system disorders. We delineate the clinical and paraclinical findings and outcome of our pediatric patients with MOG antibody seropositive disease.
METHODS: We retrospectively analyzed the clinical presentation, cerebrospinal fluid findings, magnetic resonance imaging (MRI) studies, course and outcome of children seropositive for anti-MOG IgG.
RESULTS: Total 20 children with neurological symptoms and serum anti-MOG IgG were identified from six centers in Turkey. Median age at onset was 9 years (mean 8.8 ± 5.0 years, range: 1.5-16.5 years). Final diagnoses were acute disseminated encephalomyelitis (ADEM) (n = 5), ADEM + optic neuritis (n = 4), neuromyelitis optica spectrum disorder (NMOSD) (n = 3), myelitis (n = 2), relapsing optic neuritis (n = 2), multiphasic DEM (n = 3), and unclassified relapsing demyelinating disease (n = 1). Seven/20 (35%) children experienced a single episode while 13/20 (65%) had a least one relapse during follow-up. On MRI, subcortical white matter, brainstem, and corpus callosum were preferentially involved regions. Full recovery was observed in 15/20 (75%) children.
CONCLUSION: MOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases.
METHODS: We retrospectively analyzed the clinical presentation, cerebrospinal fluid findings, magnetic resonance imaging (MRI) studies, course and outcome of children seropositive for anti-MOG IgG.
RESULTS: Total 20 children with neurological symptoms and serum anti-MOG IgG were identified from six centers in Turkey. Median age at onset was 9 years (mean 8.8 ± 5.0 years, range: 1.5-16.5 years). Final diagnoses were acute disseminated encephalomyelitis (ADEM) (n = 5), ADEM + optic neuritis (n = 4), neuromyelitis optica spectrum disorder (NMOSD) (n = 3), myelitis (n = 2), relapsing optic neuritis (n = 2), multiphasic DEM (n = 3), and unclassified relapsing demyelinating disease (n = 1). Seven/20 (35%) children experienced a single episode while 13/20 (65%) had a least one relapse during follow-up. On MRI, subcortical white matter, brainstem, and corpus callosum were preferentially involved regions. Full recovery was observed in 15/20 (75%) children.
CONCLUSION: MOG autoimmunity in children has a wide clinical spectrum, tendency to relapse, and a favourable outcome compared with other relapsing demyelinating diseases.
Предметные рубрики MeSH
AdolescentAutoantibodiesBrain StemChildChild, PreschoolDemyelinating Autoimmune Diseases, CNSEncephalomyelitis, Acute DisseminatedFemaleHumansImmunoglobulin GInfantMagnetic Resonance ImagingMaleMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaOptic NeuritisRecurrenceRetrospective StudiesTurkeyWhite Matter