Clinical neuroradiology · 2026
Time-intensity Profiles and T1-corrected Arterial Transit Time from Multi-delay Pseudo-continuous ASL with a Variable-TR Scheme for the Characterization of Adult-type Diffuse Glioma.
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Yamashita Koji, Obara Makoto, Kikuchi Kazufumi, Mikayama Ryoji, Momosaka Daichi, Kusunoki Masaoki, Kuga Daisuke, Hatae Ryusuke, Fujioka Yutaka, Otsuji Ryosuke, Wada Tatsuhiro, Tokunaga Chiaki, Van Cauteren Marc, Togao Osamu, Yoshimoto Koji, Ishigami Kousei
Аннотация
PURPOSE: The cerebral blood flow (CBF) measured by multi-delay ASL (4D-ASL) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Dynamic changes in signal intensity (SI) and arterial transit time (ATT) obtained from 4D-ASL may also be key factors in differentiating adult-type diffuse glioma. Furthermore, the longitudinal relaxation time (T1) of brain tumor may influence on CBF and ATT when using ASL techniques. Our purpose was to determine if time-intensity profiles from 4D-ASL using a variable-TR scheme and T1-corrected ATT (ATTT1corr) could distinguish among adult-type diffuse gliomas.
MATERIALS AND METHODS: The 4D-ASL with a variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A total of 14 LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATTT1corr were compared among adult-type diffuse gliomas.
RESULTS: Thirty patients were included in the study. ATT and the SI peak time in diffuse glioma with IDH-wildtype (IDHw) were significantly shorter than astrocytoma, IDH-mutant (p < 0.01, each). Moreover, ATTT1corr in astrocytoma, IDH-mutant was longer than the other types of diffuse glioma (p < 0.0001).
CONCLUSION: The 4D-ASL with a variable-TR scheme includes ATTT1corr and the SI peak time could potentially improve the differential diagnosis of adult-type diffuse gliomas.
MATERIALS AND METHODS: The 4D-ASL with a variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A total of 14 LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATTT1corr were compared among adult-type diffuse gliomas.
RESULTS: Thirty patients were included in the study. ATT and the SI peak time in diffuse glioma with IDH-wildtype (IDHw) were significantly shorter than astrocytoma, IDH-mutant (p < 0.01, each). Moreover, ATTT1corr in astrocytoma, IDH-mutant was longer than the other types of diffuse glioma (p < 0.0001).
CONCLUSION: The 4D-ASL with a variable-TR scheme includes ATTT1corr and the SI peak time could potentially improve the differential diagnosis of adult-type diffuse gliomas.