The American surgeon · 2026
Efficacy of Short- vs Long-Course Antibiotics in Treatment of Hinchey Stage 3 and 4 Diverticulitis.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Awad Abanoub A, Linnaus Maria E, Theerman Isaac L, Yang Theodore, York Justin M, Stephens Daniel, Jorge Irving A, Junker Michelle S, Cardenas Lara Francisco J, Rich Jennifer R, Kooda Kirstin J, Beckermann Jason
Аннотация
BackgroundThis study aimed to evaluate outcomes of different antibiotic durations in patients with severe diverticulitis.MethodsInitial electronic medical record review identified 2437 adult patients who underwent sigmoid colectomy. Manual chart review identified 133 patients who underwent sigmoid resection and proximal diversion for Hinchey stage 3 or 4 diverticulitis. Patients who received a short antibiotic course (SAC, ≤5 days) were compared with those who received a long antibiotic course (LAC, >5 days). The primary composite outcome included superficial, incisional, organ-space infections or death within 30 days post procedure.ResultsA total of 53 SAC patients and 55 LAC patients were identified. The composite outcome occurred more frequently in LAC patients than in SAC patients (40% vs 15%; P = .005). Organ-space infection occurred more frequently in LAC patients than in SAC patients (31% vs 13%; P = .04).ConclusionsExtended duration of antibiotics after adequate source control does not improve outcomes even in the setting of extensive intra-abdominal contamination.