Arquivos de gastroenterologia · 1999
[Treatment of unspecific ulcerative rectocolitis in a child with enemas containing butyrate. Case report].
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Assumpção I R, Rodrigues M, Barbieri D
Аннотация
OBJECTIVE: To report a promising therapy to ulcerative colitis in children.
METHODS: We report a case of ulcerative colitis in 4 years old female, who had this diagnosis since she was 1 year old. The treatment of RCU1 had an unsatisfactory response to conventional therapies (rectal and oral corticosteroids and immunosuppressive agent).
RESULTS: She showed improvement, using enemas containing butyrate, in clinical, endoscopic and histological parameters.
CONCLUSIONS: Although the role of butyrate in the treatment of ulcerative colitis still remains to be determined, we find effective response in this case. Despite evidences that butyrate may be beneficial and safety in treating refractory distal ulcerative colitis, results of controlled trials, specially in children will be necessary to prove the efficacy of this therapy.
METHODS: We report a case of ulcerative colitis in 4 years old female, who had this diagnosis since she was 1 year old. The treatment of RCU1 had an unsatisfactory response to conventional therapies (rectal and oral corticosteroids and immunosuppressive agent).
RESULTS: She showed improvement, using enemas containing butyrate, in clinical, endoscopic and histological parameters.
CONCLUSIONS: Although the role of butyrate in the treatment of ulcerative colitis still remains to be determined, we find effective response in this case. Despite evidences that butyrate may be beneficial and safety in treating refractory distal ulcerative colitis, results of controlled trials, specially in children will be necessary to prove the efficacy of this therapy.