Медицинская библиотека · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2007

Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection.

Coppola Nicola, Genovese Domenico, Pisaturo Mariantonietta, Taffon Stefania, Argentini Claudio, Pasquale Giuseppe, Sagnelli Caterina, Piccinino Felice, Rapicetta Maria, Sagnelli Evangelista

Клинический случайСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course.

METHODS

We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months.

RESULTS

Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness.

CONCLUSIONS

Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.

Для цитирования: Coppola Nicola, Genovese Domenico, Pisaturo Mariantonietta, Taffon Stefania, Argentini Claudio, Pasquale Giuseppe, Sagnelli Caterina, Piccinino Felice, Rapicetta Maria, Sagnelli Evangelista. Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007. DOI: 10.1086/513430.

Предметные рубрики MeSH

Acute Disease Adult Amino Acid Sequence Base Sequence Cholestasis Genotype Hepatitis A Hepatitis A virus Humans Male Molecular Sequence Data Severity of Illness Index

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