Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Lee Jae Min, Choi Jung Yoon, Hong Kyung Taek, Kang Hyoung Jin, Shin Hee Young, Baek Hee Jo, Kook Hoon, Kim Seongkoo, Lee Jae Wook, Chung Nack Gyun, Cho Bin, Cho Seok Goo, Park Kyung Mi, Yang Eu Jeen, Lim Young Tak, Suh Jin Kyung, Kang Sung Han, Kim Hyery, Koh Kyung Nam, Im Ho Joon, Seo Jong Jin, Cho Hee Won, Ju Hee Young, Lee Ji Won, Yoo Keon Hee, Sung Ki Woong, Koo Hong Hoe, Park Kyung Duk, Hah Jeong Ok, Kim Min Kyoung, Han Jung Woo, Hahn Seung Min, Lyu Chuhl Joo, Shim Ye Jee, Kim Heung Sik, Do Young Rok, Yoo Jae Won, Lim Yeon Jung, Jeon In Sang, Chueh Hee Won, Oh Sung Yong, Choi Hyoung Soo, Park Jun Eun, Lee Jun Ah, Park Hyeon Jin, Park Byung Kiu, Kim Soon Ki, Lim Jae Young, Park Eun Sil, Park Sang Kyu, Choi Eun Jin, Choi Young Bae, Yoon Jong Hyung, Korean Pediatric Hematology and Oncology Group (KPHOG)
Аннотация
METHODS: We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016.
RESULTS: A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% ± 2.4%, while five-year overall survival (OS) rate was 96.1% ± 1.4%: 98.7% ± 1.3%, 97.7% ± 1.6%, and 86.5% ± 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high-risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively.
CONCLUSION: This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.