Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

BACKGROUND

Gait impairment in Parkinson's disease (PD) relates to motor-cognitive interactions, yet the specific neural characteristics patterns of different individuals under various task strategies remain unclear. This study aimed to explore prefrontal activation heterogeneity in three prioritized dual-task walking (DTW) conditions and to identify subgroups based on neural activation characteristics, thus revealing differences in the integration of cognitive and motor resources.

METHODS

Thirty-nine patients were tested during their OFF-medication state. Functional near-infrared spectroscopy (fNIRS) was used to record oxygenated hemoglobin (HbO) concentrations in the prefrontal cortex during three DTW conditions: non-prioritized (NP-DTW), motor-prioritized (MP-DTW), cognition-prioritized (CP-DTW) and single task walking. Prefrontal activation patterns were analyzed using clustering and differences between subgroups in gait, cognitive, and activation modulation capacity were compared.

RESULTS

Clustering identified three subgroups: high-activity (HA), moderate-activity (MA) and low-activity group (LA). HA showed significant task modulation capacity with good gait and cognitive performance. LA, although having the lowest prefrontal activation, achieved optimal gait performance and automaticity, and superior cognition. MA showed moderate activation, but the worst gait and cognition. DTW significantly reduced gait performance, while the motor-prioritized strategy significantly mitigated gait deterioration induced by dual-tasking.

CONCLUSIONS

Patients exhibit significant heterogeneity in prefrontal activation under DTW. Different activation subgroups reflect diverse functional phenotypes. Identifying subgroups based on activation characteristics aids in precision assessment and the design of personalized interventions and could inform the development of targeted rehabilitation strategies to improve patient outcomes and quality of life.

TRIAL REGISTRATION: Chinese Clinical Trial Registry, www.chictr.org.cn, ChiCTR2300074453.