Translational vision science & technology · 2026
Impact of Age-Related Changes in Lens Shape on the Increased Risk of Posterior Capsule Opacification Observed in Pediatric Cataract Patients.
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Izuagbe Samira, Alankar Tejas, Zoller Katherine, Bhuiyan Farjana F, Obafemi Precious, Mendiaz Feabie, Vaish Bhavya, Duncan Melinda K, Wu Hongli, Tang Liping
Аннотация
PURPOSE: Posterior capsule opacification (PCO) rates are higher in young cataract patients compared to adults, a phenomenon attributed to a higher proliferative potential of young lens epithelial cells (LECs). This study investigates the hypothesis that implanting standard (adult-sized) intraocular lenses (IOLs) in pediatric patients, whose lenses are smaller and more spherical, results in a low contact between the IOL and the posterior lens capsule (PLC), thus contributing to elevated pediatric PCO rates.
METHODS: Simulated PLCs (sPLC) modeling the size and curvatures of human lenses of eight-year-old (8y-sPLC), 25-year-old (25y-sPLC), and 65-year-old (65y-sPLC) individuals were fabricated. The physical interactions between standard IOL and the sPLCs were quantified using optical coherence tomography (OCT) and adhesion force testing. Furthermore, the influence of age-dependent lens shape on young and adult primary mouse LEC responses (infiltration, proliferation, and epithelial-mesenchymal transdifferentiation [EMT]) was investigated.
RESULTS: The 8y-sPLC exhibited the least contact with IOLs, followed by 25y-sPLC and 65y-sPLC. Consequently, despite an inherent difference in cell activity, both young and adult LECs exhibited higher responses at the IOL-8y-sPLC interface compared to the 25y- and 65y-sPLC interfaces. Regression analyses confirmed that low IOL-PLC contact, observed only with 8y-sPLC, accompanied by higher cell responses from both young and adult LECs.
CONCLUSIONS: The findings suggest that the mismatch in size and curvature between pediatric PLCs and standard IOLs may be a key factor contributing to higher PCO rates observed in young cataract patients.
TRANSLATIONAL RELEVANCE: Our findings provide foundational knowledge for designing age-specific IOLs that optimize IOL-PLC contact, potentially reducing pediatric PCO incidence.
METHODS: Simulated PLCs (sPLC) modeling the size and curvatures of human lenses of eight-year-old (8y-sPLC), 25-year-old (25y-sPLC), and 65-year-old (65y-sPLC) individuals were fabricated. The physical interactions between standard IOL and the sPLCs were quantified using optical coherence tomography (OCT) and adhesion force testing. Furthermore, the influence of age-dependent lens shape on young and adult primary mouse LEC responses (infiltration, proliferation, and epithelial-mesenchymal transdifferentiation [EMT]) was investigated.
RESULTS: The 8y-sPLC exhibited the least contact with IOLs, followed by 25y-sPLC and 65y-sPLC. Consequently, despite an inherent difference in cell activity, both young and adult LECs exhibited higher responses at the IOL-8y-sPLC interface compared to the 25y- and 65y-sPLC interfaces. Regression analyses confirmed that low IOL-PLC contact, observed only with 8y-sPLC, accompanied by higher cell responses from both young and adult LECs.
CONCLUSIONS: The findings suggest that the mismatch in size and curvature between pediatric PLCs and standard IOLs may be a key factor contributing to higher PCO rates observed in young cataract patients.
TRANSLATIONAL RELEVANCE: Our findings provide foundational knowledge for designing age-specific IOLs that optimize IOL-PLC contact, potentially reducing pediatric PCO incidence.