[Levels of melatonin in serum of patients with retinitis pigmentosa].

PURPOSE: To elucidate melatonin secretion through the pineal gland in patients with night blindness.

MATERIAL AND

METHODS

Blood samples for melatonin RIA assay were taken from 14 patients at 8 o'clock a.m. and p.m., before and after 3 weeks therapy with Trental, Cocarboxylase and vitamin B12.

RESULTS

Usual rhythm of melatonin secretion was demonstrated. The applied treatment influenced melatonin secretion in the youngest group of patients.

CONCLUSION

Damage of the photoreceptors in the retina affects melatonin secretion and its circadian rhythm.