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Войти в исследования Journal of biophotonics · 2025
Photobiomodulation Exerts Anti-Inflammatory and Antioxidant Effects Reducing the Development of Tumors Elicited by 4-NQO in the Mice Tongue.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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do Carmo Filho José Ronildo Lins, Lima Iásly Costa, de Barros Silva Paulo Goberlânio, Alves Ana Paula Negreiros Nunes, Sousa Fabricio Bitu, Assreuy Ana Maria Sampaio, Mota Mário Rogério Lima
Аннотация
OBJECTIVE: Evaluate the influence of photobiomodulation in a model of oral carcinogenesis induced by 4-nitroquinoline-n-oxide (4-NQO).
SUBJECTIVE: Ninety-six Swiss mice received topical application of 1% 4-NQO on tongue dorsum, for 20 weeks. The tongue was subjected to photobiomodulation with red (71.4 J/cm2) and infrared laser (142.8 J/cm2) starting at week 0, 12, and 16. After 20 weeks, tongues were removed for the following analyzes: histological assessment, immunohistochemical reactions (cyclin D1/Ki-67/TGF-β1), quantification of MPO, n-AG, MDA, GSH, total proteins, TNF-α, IL-1β, and IL-6 levels.
RESULTS: 4-NQO showed significant increase in the frequency of carcinoma (p < 0.001), and in the immunostaining for cyclin D1/Ki-67/TGF-β1 (p < 0.005), along with increased levels of TNF- α, IL-1β, IL-6, MPO, n-AG, MDA, and total proteins (p < 0.001), that were reduced by photobiomodulation with red and infrared lasers (p < 0.005).
CONCLUSION: Photobiomodulation reduces tumor development, accompanied by reduced inflammatory cells and content of cytokines and oxidative markers associated with carcinogenesis.
SUBJECTIVE: Ninety-six Swiss mice received topical application of 1% 4-NQO on tongue dorsum, for 20 weeks. The tongue was subjected to photobiomodulation with red (71.4 J/cm2) and infrared laser (142.8 J/cm2) starting at week 0, 12, and 16. After 20 weeks, tongues were removed for the following analyzes: histological assessment, immunohistochemical reactions (cyclin D1/Ki-67/TGF-β1), quantification of MPO, n-AG, MDA, GSH, total proteins, TNF-α, IL-1β, and IL-6 levels.
RESULTS: 4-NQO showed significant increase in the frequency of carcinoma (p < 0.001), and in the immunostaining for cyclin D1/Ki-67/TGF-β1 (p < 0.005), along with increased levels of TNF- α, IL-1β, IL-6, MPO, n-AG, MDA, and total proteins (p < 0.001), that were reduced by photobiomodulation with red and infrared lasers (p < 0.005).
CONCLUSION: Photobiomodulation reduces tumor development, accompanied by reduced inflammatory cells and content of cytokines and oxidative markers associated with carcinogenesis.