Медицинская библиотека · Nature communications · 2020
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
Hofer Edith, Roshchupkin Gennady V, Adams Hieab H H, Knol Maria J, Lin Honghuang, Li Shuo, Zare Habil, Ahmad Shahzad, Armstrong Nicola J, Satizabal Claudia L, Bernard Manon, Bis Joshua C, Gillespie Nathan A, Luciano Michelle, Mishra Aniket, Scholz Markus, Teumer Alexander, Xia Rui, Jian Xueqiu, Mosley Thomas H, Saba Yasaman, Pirpamer Lukas, Seiler Stephan, Becker James T, Carmichael Owen, Rotter Jerome I, Psaty Bruce M, Lopez Oscar L, Amin Najaf, van der Lee Sven J, Yang Qiong, Himali Jayandra J, Maillard Pauline, Beiser Alexa S, DeCarli Charles, Karama Sherif, Lewis Lindsay, Harris Mat, Bastin Mark E, Deary Ian J, Veronica Witte A, Beyer Frauke, Loeffler Markus, Mather Karen A, Schofield Peter R, Thalamuthu Anbupalam, Kwok John B, Wright Margaret J, Ames David, Trollor Julian, Jiang Jiyang, Brodaty Henry, Wen Wei, Vernooij Meike W, Hofman Albert, Uitterlinden André G, Niessen Wiro J, Wittfeld Katharina, Bülow Robin, Völker Uwe, Pausova Zdenka, Bruce Pike G, Maingault Sophie, Crivello Fabrice, Tzourio Christophe, Amouyel Philippe, Mazoyer Bernard, Neale Michael C, Franz Carol E, Lyons Michael J, Panizzon Matthew S, Andreassen Ole A, Dale Anders M, Logue Mark, Grasby Katrina L, Jahanshad Neda, Painter Jodie N, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Pizzagalli Fabrizio, Stein Jason L, Thompson Paul M, Medland Sarah E, ENIGMA consortium, Sachdev Perminder S, Kremen William S, Wardlaw Joanna M, Villringer Arno, van Duijn Cornelia M, Grabe Hans J, Longstreth William T, Fornage Myriam, Paus Tomas, Debette Stephanie, Ikram M Arfan, Schmidt Helena, Schmidt Reinhold, Seshadri Sudha
СтатьяМетаанализResearch Support, American Recovery and Reinvestment ActПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПеревод пока не подготовлен
Аннотация
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Для цитирования: Hofer Edith, Roshchupkin Gennady V, Adams Hieab H H, Knol Maria J, Lin Honghuang, Li Shuo, Zare Habil, Ahmad Shahzad, Armstrong Nicola J, Satizabal Claudia L, Bernard Manon, Bis Joshua C, Gillespie Nathan A, Luciano Michelle, Mishra Aniket, Scholz Markus, Teumer Alexander, Xia Rui, Jian Xueqiu, Mosley Thomas H, Saba Yasaman, Pirpamer Lukas, Seiler Stephan, Becker James T, Carmichael Owen, Rotter Jerome I, Psaty Bruce M, Lopez Oscar L, Amin Najaf, van der Lee Sven J, Yang Qiong, Himali Jayandra J, Maillard Pauline, Beiser Alexa S, DeCarli Charles, Karama Sherif, Lewis Lindsay, Harris Mat, Bastin Mark E, Deary Ian J, Veronica Witte A, Beyer Frauke, Loeffler Markus, Mather Karen A, Schofield Peter R, Thalamuthu Anbupalam, Kwok John B, Wright Margaret J, Ames David, Trollor Julian, Jiang Jiyang, Brodaty Henry, Wen Wei, Vernooij Meike W, Hofman Albert, Uitterlinden André G, Niessen Wiro J, Wittfeld Katharina, Bülow Robin, Völker Uwe, Pausova Zdenka, Bruce Pike G, Maingault Sophie, Crivello Fabrice, Tzourio Christophe, Amouyel Philippe, Mazoyer Bernard, Neale Michael C, Franz Carol E, Lyons Michael J, Panizzon Matthew S, Andreassen Ole A, Dale Anders M, Logue Mark, Grasby Katrina L, Jahanshad Neda, Painter Jodie N, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Pizzagalli Fabrizio, Stein Jason L, Thompson Paul M, Medland Sarah E, ENIGMA consortium, Sachdev Perminder S, Kremen William S, Wardlaw Joanna M, Villringer Arno, van Duijn Cornelia M, Grabe Hans J, Longstreth William T, Fornage Myriam, Paus Tomas, Debette Stephanie, Ikram M Arfan, Schmidt Helena, Schmidt Reinhold, Seshadri Sudha. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.. Nature communications. 2020. DOI: 10.1038/s41467-020-18367-y.
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