Медицинская библиотека · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2009

Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children.

Pomarico Luciana, Cerqueira Daniella Ferraz, de Araujo Soares Rosangela Maria, de Souza Ivete Pomarico Ribeiro, de Araujo Castro Gloria Fernanda Barbosa, Socransky Sigmund, Haffajee Anne, Teles Ricardo Palmier

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVES

The aim was to examine the impact of antiretroviral therapy on the prevalence of oral candidiasis, recovery of oral Candida spp. , and salivary levels of total secretory immunoglobulin A (SIgA) and Candida-specific SIgA in human immunodeficiency virus (HIV)-infected children.

STUDY

DESIGN

Sixty-six HIV+ and 40 HIV- children were cross-sectionally examined for the presence of oral lesions. Whole stimulated saliva samples were collected for the identification of Candida spp. using culture and measurement of total and specific SIgA using enzyme-linked immunosorbent assay (ELISA).

RESULTS

The HIV+ children had a higher prevalence of oral candidiasis (P < .05), higher frequency of detection of Candida spp. (P < .05), and higher levels of total (P < .05) and Candida-specific SIgA (P < .001) than the HIV- children. Among the HIV+ subjects, antiretroviral users had lower viral loads (P < .001) and lower levels of Candida spp. (P < .05) and total SIgA (P < .05) compared with antiretroviral nonusers.

CONCLUSIONS

The use of antiretroviral therapy was associated with decreases in the prevalence of oral candidiasis. This diminished exposure to Candida spp. was accompanied by decreases in levels of total and Candida-specific SIgA.

Для цитирования: Pomarico Luciana, Cerqueira Daniella Ferraz, de Araujo Soares Rosangela Maria, de Souza Ivete Pomarico Ribeiro, de Araujo Castro Gloria Fernanda Barbosa, Socransky Sigmund, Haffajee Anne, Teles Ricardo Palmier. Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children.. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2009. DOI: 10.1016/j.tripleo.2009.05.008.

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