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Войти в исследования AIDS (London, England) · 2025
Penile human papillomavirus prevalence in circumcised sexual minority men with and without HIV.
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Nampota-Nkomba Nginache, Mohanty Kareshma, Adebiyi Ruxton, Ekeh Charles, Schumaker Lisa M, Suleiman Kareemah T, Powell Laura, Lombardi Kara, Ambulos Nicholas P, Shoyemi Elizabeth, Tiamiyu Abdulwasiu B, Homan Michael G, Sajadi Mohammad M, Bentzen Søren M, Cullen Kevin J, Crowell Trevor A, Nowak Rebecca G, TRUST/RV368 Study Group
Аннотация
OBJECTIVE: Understanding the burden of penile human papillomavirus (HPV) among high-risk groups is essential to inform tailored prevention strategies to reduce HPV-related morbidity. We estimated the prevalence of penile HPV and its association with HIV among circumcised sexual minority men (SMM).
DESIGN: A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.
METHODS: Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.
RESULTS: Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% ( n = 351) were living with HIV. The prevalence of any ( n = 362) and high-risk ( n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.
CONCLUSION: Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.
DESIGN: A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.
METHODS: Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.
RESULTS: Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% ( n = 351) were living with HIV. The prevalence of any ( n = 362) and high-risk ( n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.
CONCLUSION: Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.