[Correlation between menstruation disorders and insulin resistance].

UNLABELLED: The association between menstrual cylce abnormalities and insulin resistance in parallel to further clinical and biochemical findings was evaluated.

MATERIAL AND

METHODS

An observational, retrospective and transversal study was performed through a review of clinical charts of female patients (18-35 years old) who had undergone pelvic ultrasound seen at our service of Reproductive Biology in the Hospital Juárez de México form January 1996 to May 2002 with the following: abnormal menses (n = 22), eumenorrhea as controls (n = 28); without uterine or ovarian tumors, endocrine dysfunction or contraceptives. We assessed body mass index (BMI), waist hip ratio (WHR), ferriman, acanthosis nigricans, lipid profile and hormonal quantification. We used the HOMA procedure (18) for diagnosis of insulin resistance (glucose nmol/L (18 x insulin mIU/mL (22.5 = > 5.2.

RESULTS

The abnormal menstrual patterns found were opsomenorrhea (n = 34), opsoamenorrhea (n = 17), amenorrhea (n = 23), proiomenorrhea (n = 3) and eumenorrheic controls (n = 28). There were no differences in age and BMI. The frequency of insulin resistance found was: controls (35.7%), opsomenorrhea (41.17%), opsoamenorrhea (41.17%), amenorrhea (78.26%) and proiomenorrhea (0%); the group with amenorrhea was statistically significant (P < 0.002). Those patients with obesity found in our groups exhibited a highest percentage of insulin resistance (Pearson: 0.37). WHR bigger 0.85 prevailed among patients with insulin resistance (P = 0.039). The finding of polycystic ovary was prevalent among opsoamenorrhea and opsomenorrhea patients with insulin resistance. Hyperandrogenemia and polycystic ovaries showed a higher percentage in amenorrheic and opsomenorrheic females with insulin resistance (P = < 0.05).

COMMENTS: The amenorrhea symptom had a significant correlation with insulin resistance and it was also associated to obesity, acanthosis and polycystic ovaries.