Journal of cutaneous pathology · 2002
Host-vs.-altered-host eruptions in patients on liposomal doxorubicin.
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Skelton Henry, Linstrum Jill, Smith Kathleen
Аннотация
BACKGROUND: Anthracycline antitumor antibiotics are the most commonly used chemotherapeutic agents. One of these is doxorubicin. Liposomal doxorubicin was developed as a drug delivery system in order to deliver the active drug intracellularly while decreasing the systemic toxicity, particularly hematological and cardiac toxicity.
METHODS: The clinical and histologic findings of the cutaneous eruptions of associated with liposomal doxorubicin are reviewed.
RESULTS: The eruptions occurred in three women with metastatic ovarian carcinoma who were treated with liposomal doxorubicin. These three patients developed erythematous macular/papular to plaque cutaneous lesions, and in one patient a vesicular component. The eruptions involved the trunk and extremities approximately 3-4 weeks after completions of therapy. None of the patients had any documented infections, and none of the patients had symptoms other than pruritus. The eruptions cleared over a period of weeks to months. Histologic features included an interface dermatitis with numerous apoptotic/dyskeratotic cells within the epidermis, with involvement the intra-epidermal sweat ducts and the infundibulum of hair follicles.
CONCLUSION: We believe that these eruptions represented a chemotherapy induced host-vs.-altered host reaction.
METHODS: The clinical and histologic findings of the cutaneous eruptions of associated with liposomal doxorubicin are reviewed.
RESULTS: The eruptions occurred in three women with metastatic ovarian carcinoma who were treated with liposomal doxorubicin. These three patients developed erythematous macular/papular to plaque cutaneous lesions, and in one patient a vesicular component. The eruptions involved the trunk and extremities approximately 3-4 weeks after completions of therapy. None of the patients had any documented infections, and none of the patients had symptoms other than pruritus. The eruptions cleared over a period of weeks to months. Histologic features included an interface dermatitis with numerous apoptotic/dyskeratotic cells within the epidermis, with involvement the intra-epidermal sweat ducts and the infundibulum of hair follicles.
CONCLUSION: We believe that these eruptions represented a chemotherapy induced host-vs.-altered host reaction.
Предметные рубрики MeSH
Acanthosis NigricansAdministration, TopicalAgedAged, 80 and overAnti-Inflammatory AgentsAntibiotics, AntineoplasticAntineoplastic AgentsApoptosisCarcinomaCytotoxicity, ImmunologicDoxorubicinDrug EruptionsErythemaFemaleFluocinonideGlucocorticoidsHumansKeratosisLiposomesMiddle AgedOvarian NeoplasmsTreatment Outcome