[Pollen allergen sensitization feature of seasonal allergic rhinitis in children and adolescents in northern China].

Objective:The prevalence of seasonal allergic rhinitis（SAR） is high in children and adolescents population. The aim of this study is to explore the feature of pollen allergen sensitization of SAR in children and adolescents . Method:Children and adolescents with self-reported seasonal allergic rhinitis in an allergy center of a tertiary hospital were enrolled and received skin prick test（SPT） of 13 common pollen allergens. SAR was defined with positive SPT to any pollen allergen. SPSS software was applied to analyze the differences in age, gender, sensitization pattern. Result:In total, 374（85.6%） SAR cases with self-reported seasonal allergic rhinitis were enrolled,including 213 males （57%） and 161 females （43%）. There are 198 children （2-12 years old） and 176 adolescents （13-17 years old）. The highest sensitization rate was presented in Chenopodium （73.8%） , Humulus（67.6%） and Artemisia （64.7%）.The severe sensitization was presented in Artemisia（53.7%）, Humulus（46.8%） and Chenopodium （42.0%）. No gender difference was found among different pollen allergens and sensitization patterns（P>0.05）. No age difference was found between different pollen allergens and sensitization patterns except that Cupressaceae was higher in adolescent group than that in children group（55.1% vs 42.9%, P=0.023）. Poly-sensitization rate was 57.2% in tree pollens, 59.6% in weed pollens and 81.3% in total. Significant correlation was found among different tree pollens and weed pollens（P<0.01）. Tree pollen sensitization was significantly correlated with weed pollens except Cupressaceae（P<0.01）. The mono-sensitization rate is low in all 4 weed pollen allergens ranged from 1% to 8% while 49.2% of SAR patients were allergic to all of the 4 weed pollen allergens. Conclusion:The prevalent pollen allergens in SAR were similar in children and adolescent comparing to adults. No obvious gender and age differences were found. An extensive co-sensitizations were found among pollens especially in weed pollens.