Digital treatment planning and clear aligners therapy: Current evidence-based perspectives in growing patients - A narrative review with case reports.

The mixed dentition phase represents a fundamental step for guiding occlusal development and addressing dento-skeletal discrepancies in growing patients. Among available modalities, clear aligners (CA) have emerged as a viable option in Phase I therapy, offering benefits in terms of aesthetics, hygiene, and comfort. The present narrative review explores current evidence on CA therapy in growing patients and analyses the biomechanical issues of CA therapy. Two clinical cases are presented to illustrate treatment protocols highlighting the importance of customized digital planning in the application of CA in early orthodontic intervention to obtain aesthetic and functional results.