The Journal of dermatological treatment · 2025
A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Shao Hui, Wang Lu, Wang Yilong, Wang Chuan, Chen Lujia, Tang Jieying, Zhang Shihong, Chen Qiang, Dong Ruijia, Liao Xueyin, Hou Yikang, Yang Jianmin, Li Weiwei
Аннотация
BACKGROUND: Intense pulsed light (IPL) therapy is widely used for skin rejuvenation, but often impairs the skin barrier, causing discomfort and prolonging recovery.
OBJECTIVES: To evaluate the efficacy and safety of a novel moisturizer containing saccharide isomerate in restoring skin barrier function and alleviating symptoms after IPL treatment in Chinese population.
METHODS: In this split-face study, thirty subjects with skin aging received a single IPL treatment. Each participant applied the test moisturizer containing saccharide isomerate to one randomly assigned cheek and the control moisturizer to the contralateral side twice daily for 7 days. Key barrier function parameters were measured at baseline and repeatedly during study period. Adverse events were assessed at each of these follow-up time points. Additionally, overall subject satisfaction was evaluated at the end of the study.
RESULTS: The test side showed significantly greater improvement in all biometric parameters (all p < 0.05) and was associated with significantly less subjective discomfort. Both formulations were well-tolerated with no related adverse events.
CONCLUSION: The saccharide isomerate-based moisturizer significantly accelerates skin barrier recovery, improves hydration, reduces erythema, alleviates discomfort and has a good safety profile with high subject satisfaction, making it a promising new option in the field of post-photoelectric surgery care.
OBJECTIVES: To evaluate the efficacy and safety of a novel moisturizer containing saccharide isomerate in restoring skin barrier function and alleviating symptoms after IPL treatment in Chinese population.
METHODS: In this split-face study, thirty subjects with skin aging received a single IPL treatment. Each participant applied the test moisturizer containing saccharide isomerate to one randomly assigned cheek and the control moisturizer to the contralateral side twice daily for 7 days. Key barrier function parameters were measured at baseline and repeatedly during study period. Adverse events were assessed at each of these follow-up time points. Additionally, overall subject satisfaction was evaluated at the end of the study.
RESULTS: The test side showed significantly greater improvement in all biometric parameters (all p < 0.05) and was associated with significantly less subjective discomfort. Both formulations were well-tolerated with no related adverse events.
CONCLUSION: The saccharide isomerate-based moisturizer significantly accelerates skin barrier recovery, improves hydration, reduces erythema, alleviates discomfort and has a good safety profile with high subject satisfaction, making it a promising new option in the field of post-photoelectric surgery care.