AI-enhanced Centiloid quantification of amyloid PET images.
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Bourgeat Pierrick, Fripp Jurgen, Lebrat Leo, Xia Ying, Feizpour Azadeh, Cox Timothy, Zisis Georgios, Gillman Ashley, Goyal Manu S, Tosun Duygu, Benzinger Tammie Ls, LaMontagne Pamela, Breakspear Michael, Lupton Michelle K, Short Cathy, Adam Robert, Robertson Joanne S, Sperling Reisa, O'Bryant Sid E, Johnson Sterling C, Jr Clifford R Jack, Schwarz Christopher G, Barkhof Frederik, Farrar Gill, Bollack Ariane, Collij Lyduine E, Landau Susan, Koeppe Robert, Alzheimer's Disease Neuroimaging Initiative, OASIS3, A4/LEARN Study Team, AMYPAD consortium, Health and Aging Brain Study (HABS‐HD) Study Team, Mayo Clinic Study of Aging, WRAP, ADNI‐DOD, PISA, ADNeT, AIBL research group, Morris John C, Weiner Michael W, Villemagne Victor L, Masters Colin L, Rowe Christopher C, Dore Vincent
Аннотация
METHODS: This study introduces DeepSUVR, a deep learning method to correct Centiloid quantification, by penalizing implausible longitudinal trajectories during training. The model was trained using data from 2,129 participants (7,149 Aβ positron emission tomography [PET] scans) in the Australian Imaging, Biomarkers and Lifestyle Study of ageing (AIBL)/Alzheimer's Disease Neuroimaging Initiative (ADNI) and validated using 15,807 Aβ PET scans from 10,543 participants across 10 external datasets.
RESULTS: DeepSUVR increased correlation between tracers, and reduced variability in the Aß-negatives. It showed significantly stronger association with cognition, visual reads, neuropathology, and increased longitudinal consistency between studies. DeepSUVR also increased the effect size for detecting small treatment related slowing of amyloid accumulation in the A4 study.
DISCUSSION: DeepSUVR substantially advances Aβ PET quantification, outperforming all standard approaches, which is particularly important for clinical decision making and to detect subtle or early changes in Aβ.
HIGHLIGHTS: Novel artificial intelligence (AI)-method that penalizes biologically implausible longitudinal trajectories, enabling the model to learn standardized uptake value ratios (SUVR) correction factors without requiring longitudinal data at inference time. Improves Centiloid consistency across tracers and studies, significantly enhancing cross-sectional and longitudinal amyloid positron emission tomography (PET) quantification. DeepSUVR-derived Centiloids show stronger associations with cognition, visual reads, and neuropathology. Longitudinal variability is reduced three- to five-fold, enabling more reliable tracking of amyloid accumulation and better detection of treatment effects. Novel reference and target masks derived from DeepSUVR replicate most of the model's performance, offering a practical alternative for integration into existing pipelines.