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DOI 10.18632/aging.101151

Медицинская библиотека · Aging · 2017

The complex genetics of gait speed: genome-wide meta-analysis approach.

Ben-Avraham Dan, Karasik David, Verghese Joe, Lunetta Kathryn L, Smith Jennifer A, Eicher John D, Vered Rotem, Deelen Joris, Arnold Alice M, Buchman Aron S, Tanaka Toshiko, Faul Jessica D, Nethander Maria, Fornage Myriam, Adams Hieab H, Matteini Amy M, Callisaya Michele L, Smith Albert V, Yu Lei, De Jager Philip L, Evans Denis A, Gudnason Vilmundur, Hofman Albert, Pattie Alison, Corley Janie, Launer Lenore J, Knopman Davis S, Parimi Neeta, Turner Stephen T, Bandinelli Stefania, Beekman Marian, Gutman Danielle, Sharvit Lital, Mooijaart Simon P, Liewald David C, Houwing-Duistermaat Jeanine J, Ohlsson Claes, Moed Matthijs, Verlinden Vincent J, Mellström Dan, van der Geest Jos N, Karlsson Magnus, Hernandez Dena, McWhirter Rebekah, Liu Yongmei, Thomson Russell, Tranah Gregory J, Uitterlinden Andre G, Weir David R, Zhao Wei, Starr John M, Johnson Andrew D, Ikram M Arfan, Bennett David A, Cummings Steven R, Deary Ian J, Harris Tamara B, Kardia Sharon L R, Mosley Thomas H, Srikanth Velandai K, Windham Beverly G, Newman Ann B, Walston Jeremy D, Davies Gail, Evans Daniel S, Slagboom Eline P, Ferrucci Luigi, Kiel Douglas P, Murabito Joanne M, Atzmon Gil

СтатьяМетаанализResearch Support, N.I.H., IntramuralПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Prior research indicates that disease-related stigma (e.g., mpox stigma) tends to perpetuate even after the conclusion of the infection. For instance, HIV stigma remains highly prevalent despite the proliferation of stigma-reducing public health initiatives and campaigns. Perpetuation of these stigmas, especially association avoidance well after recovery, has somewhat confounded scholars and public health officials alike. In this study, using the concept of dispositional moral attribution, we offer an explanation for this perpetuated stigma.

METHODOLOGY: We developed multiple logistic regression models using data from the mpox substudy of the Keeping it LITE study. This cross-sectional survey was conducted in Illinois, USA in September 2022 and collected the attitudes of 226 sexual minority individuals towards the 2022 mpox outbreak in Illinois.

RESULTS/DISCUSSION: Findings indicate a significant positive relationship between moral attribution and association avoidance of those who have recovered from mpox. Individuals who believe those with mpox have participated in immoral activities are 4.5 times as likely to avoid association with those who recovered from mpox compared to those who do not associate mpox with immoral activities.

CONCLUSION

We conclude that chronic stigmatization, in the form of association avoidance, is more likely when the stigmatized status of an individual is presumed to be the result of their own immoral behavior. Destigmatization campaigns are encouraged to take this finding into account when framing their efforts.

Для цитирования: Ben-Avraham Dan, Karasik David, Verghese Joe, Lunetta Kathryn L, Smith Jennifer A, Eicher John D, Vered Rotem, Deelen Joris, Arnold Alice M, Buchman Aron S, Tanaka Toshiko, Faul Jessica D, Nethander Maria, Fornage Myriam, Adams Hieab H, Matteini Amy M, Callisaya Michele L, Smith Albert V, Yu Lei, De Jager Philip L, Evans Denis A, Gudnason Vilmundur, Hofman Albert, Pattie Alison, Corley Janie, Launer Lenore J, Knopman Davis S, Parimi Neeta, Turner Stephen T, Bandinelli Stefania, Beekman Marian, Gutman Danielle, Sharvit Lital, Mooijaart Simon P, Liewald David C, Houwing-Duistermaat Jeanine J, Ohlsson Claes, Moed Matthijs, Verlinden Vincent J, Mellström Dan, van der Geest Jos N, Karlsson Magnus, Hernandez Dena, McWhirter Rebekah, Liu Yongmei, Thomson Russell, Tranah Gregory J, Uitterlinden Andre G, Weir David R, Zhao Wei, Starr John M, Johnson Andrew D, Ikram M Arfan, Bennett David A, Cummings Steven R, Deary Ian J, Harris Tamara B, Kardia Sharon L R, Mosley Thomas H, Srikanth Velandai K, Windham Beverly G, Newman Ann B, Walston Jeremy D, Davies Gail, Evans Daniel S, Slagboom Eline P, Ferrucci Luigi, Kiel Douglas P, Murabito Joanne M, Atzmon Gil. The complex genetics of gait speed: genome-wide meta-analysis approach.. Aging. 2017. DOI: 10.18632/aging.101151.

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