Медицинская библиотека · Emerging infectious diseases · 2026

Epidemiology of and Risk Factors for Amebic Meningoencephalitis, Kerala, India, 2025.

Sivanandan Harikumar, Thangaraj Jeromie Wesley Vivian, Saritha Ala, Bhaskar Anitha, Reghukumar Aravind, Rahim Asuma A, Vadakkayil Bindu, Sujatha Chintha, Amma Karthika Meenakshy, Thali Manoj Arayakandy, Amma Prathibha M Thankamoni, Chandran Priya, Ravindran Rekha Melathuparambil, Prakash Remya, Jacob Sabitha Rose, Vadekkandiyil Shameer, Chenayil Shubin, Bhaskarannair Unnikrishnan, Saraswthy Abhishek Gopalakrishnan, Moorkoth Anitha Puduvail, Kanchana Bhagyalakshmi Mahavan, George Biju, Gopal Dinesh, Hassan Heera, Johnson Jincy, Divakaran Kiran Raj, Bhama M C Sathya, Shaju Megha, Abraham Minu, Ramankutty Neetha T, Sankar Pressy, Sajeev Priyanka, Narayanankutty Saritha, Sasikumari O, Muthukutty Sujina Cheraparambil, Anish Thekkumkara Surendran, Kadavath Vishnunath, Raman Aruna, Santhakumari Bindu Gopalakrishnan, Ramakrishnan Gayathri, Panarkandy Geetha, Puthanpurayil Jayakrishnan Machinery, Karippoth Mohandas Nair, Mohammed Shameem Anathan, Sugunan Sheeja, Gangadharan Sindhu Thekkile, Ushakumari Anuja, Radhakrishnan Chandni, Sreekumar Easwaran, Anaswara Naveen, Indu Pillaveetil Sathyadas, Pareri Reetha Kakkarakandiyil, Sunija Sahadevan, Govindan Sajeeth Kumar Keeriyatt, Johnson Jaichand, Jaya Ajan Maheswaran, Sushan Abey, Vaman Raman Swathy, Gopalakrishnan Lakshmi Geetha, Vijayalekshmi Arun P, Harikrishnan Dinesh Kumar, Ramasamy Sabarinathan, Krishna Navaneeth S, Kollengode Viswanathan V, Joseph Reena K, Goyal Vinay, Khobragade Rajan, Murhekar Manoj V, AME Study Group

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Аннотация

Amebic meningoencephalitis (AME) is a highly fatal central nervous system infection caused by various free-living amebae. We describe epidemiology of AME cases from Kerala, India, during January 1-November 11, 2025, and identify behavioral risk factors associated with real-time PCR-confirmed Acanthamoeba spp. infection through a matched case-control study. We identified 159 AME case-patients, of which 67 (42.1%) tested positive for Acanthamoeba spp. amebae. Most AME cases were reported from 4 districts, peaking during the monsoon and postmonsoon periods. Exposure to natural water bodies for swimming or bathing and using nonchlorinated water for domestic purposes were associated with AME. History of maxillofacial injury or nasal surgery with subsequent exposure to natural water bodies and washing ulcers or skin lesions in natural water bodies were associated with higher odds of disease. Targeted risk communication about safe water practices and routine chlorination of domestic water sources could help reduce AME risk in affected communities.

Для цитирования: Sivanandan Harikumar, Thangaraj Jeromie Wesley Vivian, Saritha Ala, Bhaskar Anitha, Reghukumar Aravind, Rahim Asuma A, Vadakkayil Bindu, Sujatha Chintha, Amma Karthika Meenakshy, Thali Manoj Arayakandy, Amma Prathibha M Thankamoni, Chandran Priya, Ravindran Rekha Melathuparambil, Prakash Remya, Jacob Sabitha Rose, Vadekkandiyil Shameer, Chenayil Shubin, Bhaskarannair Unnikrishnan, Saraswthy Abhishek Gopalakrishnan, Moorkoth Anitha Puduvail, Kanchana Bhagyalakshmi Mahavan, George Biju, Gopal Dinesh, Hassan Heera, Johnson Jincy, Divakaran Kiran Raj, Bhama M C Sathya, Shaju Megha, Abraham Minu, Ramankutty Neetha T, Sankar Pressy, Sajeev Priyanka, Narayanankutty Saritha, Sasikumari O, Muthukutty Sujina Cheraparambil, Anish Thekkumkara Surendran, Kadavath Vishnunath, Raman Aruna, Santhakumari Bindu Gopalakrishnan, Ramakrishnan Gayathri, Panarkandy Geetha, Puthanpurayil Jayakrishnan Machinery, Karippoth Mohandas Nair, Mohammed Shameem Anathan, Sugunan Sheeja, Gangadharan Sindhu Thekkile, Ushakumari Anuja, Radhakrishnan Chandni, Sreekumar Easwaran, Anaswara Naveen, Indu Pillaveetil Sathyadas, Pareri Reetha Kakkarakandiyil, Sunija Sahadevan, Govindan Sajeeth Kumar Keeriyatt, Johnson Jaichand, Jaya Ajan Maheswaran, Sushan Abey, Vaman Raman Swathy, Gopalakrishnan Lakshmi Geetha, Vijayalekshmi Arun P, Harikrishnan Dinesh Kumar, Ramasamy Sabarinathan, Krishna Navaneeth S, Kollengode Viswanathan V, Joseph Reena K, Goyal Vinay, Khobragade Rajan, Murhekar Manoj V, AME Study Group. Epidemiology of and Risk Factors for Amebic Meningoencephalitis, Kerala, India, 2025.. Emerging infectious diseases. 2026. DOI: 10.3201/eid3209.260492.

Предметные рубрики MeSH

Humans India Risk Factors Acanthamoeba Amebiasis Central Nervous System Protozoal Infections Male Female Case-Control Studies Child Child, Preschool Adolescent Adult Infant

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