Japanese journal of infectious diseases · 2015
Genomic Analysis of Single Nucleotide Polymorphisms Asp299Gly and Thr399Ile in Japanese Patients with Invasive Aspergillosis.
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Aki Kyoko, Okubo Yoichiro, Nanjo Hiroshi, Ishiwatari Takao, Nihonyanagi Yasuhiro, Tochigi Naobumi, Wakayama Megumi, Nemoto Tetsuo, Fukutake Katsunori, Shinozaki Minoru, Hori Yasuhiro, Masuda Hirotake, Shibuya Kazutoshi
Аннотация
Single nucleotide polymorphisms (SNPs) 1063A/G (Asp299Gly) and 1363C/T (Thr399Ile) in the gene encoding Toll-like receptor 4 (TLR4) increase susceptibility to invasive aspergillosis. However, limited information is available on the prevalence of these SNPs in Japan. Therefore, we surveyed these TLR4 SNPs by using formalin-fixed and paraffin-embedded tissue blocks obtained from autopsies of patients with invasive pulmonary aspergillosis. Tissue samples of approximately 30% patients were included in genomic analysis. However, none of these samples showed the presence of TLR4 Asp299Gly and Thr399Ile polymorphisms. Thus, the present study provided information on the prevalence of TLR4 SNPs in Japanese patients with invasive aspergillosis and indicated that these SNPs played a minor role in increasing the susceptibility of Japanese individuals to invasive aspergillosis.