Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 1998
Morphologic effects of glycerol on the mental nerve.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
al-Khateeb T L
Аннотация
OBJECTIVES: In recent years, injection of pure glycerol has been used successfully for the treatment of trigeminal neuralgia. However, the mode of action of this therapy remains unclear. The present experiment was undertaken to examine histologically the morphologic changes produced by extraneural injections of pure glycerol into the dog mental nerve.
STUDY DESIGN: Under direct vision, glycerol was injected extraneurally into the mental foramen on one side of the lower jaw of each of nine dogs. Physiologic saline solution was the control on the contralateral side of each animal. Animals were killed at 1, 3, and 7 days after the application of glycerol, and the mental nerve specimens were examined by light microscopy.
RESULTS: Results showed that extraneural application of pure glycerol in the vicinity of the dog mental nerve is not associated with structural changes. No signs of nerve degeneration or other morphologic changes were observed for any of the experimental and control specimens in any of the time intervals studied.
CONCLUSIONS: It can be concluded that despite the encouraging clinical results related to extraneural application of pure glycerol for treatment of trigeminal neuralgia, glycerol produces its effect without inducing any morphologic or destructive changes in the peripheral nerve. A probable explanation of the temporary clinical effectiveness of glycerol in relieving trigeminal neuralgia is discussed.
STUDY DESIGN: Under direct vision, glycerol was injected extraneurally into the mental foramen on one side of the lower jaw of each of nine dogs. Physiologic saline solution was the control on the contralateral side of each animal. Animals were killed at 1, 3, and 7 days after the application of glycerol, and the mental nerve specimens were examined by light microscopy.
RESULTS: Results showed that extraneural application of pure glycerol in the vicinity of the dog mental nerve is not associated with structural changes. No signs of nerve degeneration or other morphologic changes were observed for any of the experimental and control specimens in any of the time intervals studied.
CONCLUSIONS: It can be concluded that despite the encouraging clinical results related to extraneural application of pure glycerol for treatment of trigeminal neuralgia, glycerol produces its effect without inducing any morphologic or destructive changes in the peripheral nerve. A probable explanation of the temporary clinical effectiveness of glycerol in relieving trigeminal neuralgia is discussed.