Infectious diseases (London, England) · 2026
Demographic and epidemiological factors associated with COVID-19 superspreading persons in Gangwon province.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oh Won Sup, Bae Sunhak, Kim Eunmi, Kim Saerom, Lim Chaeyun, Lee Yerin, Kim Yeojin, Jeong Seungmin
Аннотация
BACKGROUND: Superspreading persons (SSPs) drive marked heterogeneity in SARS-CoV-2 transmission, yet quantitative evidence on their determinants in community settings remains limited.
OBJECTIVES: To quantify the impact of SSPs and identify demographic, virologic, and contextual correlates of superspreading in Gangwon Province, Korea.
METHODS: We analysed province-wide epidemiological investigation records for laboratory-confirmed COVID-19 from 21 February 2020 to 31 January 2022. Transmission networks linking index and secondary cases were reconstructed. Superspreaders were prespecified as individuals generating ≥7 secondary infections. Offspring counts were modelled with a negative binomial distribution; multivariable logistic regression estimated adjusted odds ratios for age, vaccination, symptoms at diagnosis, PCR cycle-threshold (Ct), occupation, exposure setting, and viral variant based on specimen date.
RESULTS: Among 15,300 community-acquired cases, offspring counts followed a negative binomial distribution(κ = 0.36). Most cases generated ≤6 secondaries, whereas 164 cases (1.1%) met the superspreader criterion and accounted for 1,571 downstream infections (11.3%). Higher odds of superspreading were observed among ages 0-19 (aOR 1.86) and 40-59 (1.84), the unvaccinated (1.64), those symptomatic at diagnosis (2.13), individuals with Ct <16.0 (2.54) or 16.0-23.9 (2.15), white-collar workers (1.68), same-facility exposures (2.39), and cases with an unknown source of infection (3.91). Superspreading odds also varied across variant-dominant periods inferred from specimen dates, although confidence intervals included unity.
CONCLUSION: SARS-CoV-2 transmission in Gangwon was highly overdispersed, with a small minority of cases responsible for a disproportionate share of spread. Targeted vaccination, rapid isolation of symptomatic or low-Ct index cases, and strengthened controls in high-risk workplaces and shared facilities may help blunt future superspreading.
OBJECTIVES: To quantify the impact of SSPs and identify demographic, virologic, and contextual correlates of superspreading in Gangwon Province, Korea.
METHODS: We analysed province-wide epidemiological investigation records for laboratory-confirmed COVID-19 from 21 February 2020 to 31 January 2022. Transmission networks linking index and secondary cases were reconstructed. Superspreaders were prespecified as individuals generating ≥7 secondary infections. Offspring counts were modelled with a negative binomial distribution; multivariable logistic regression estimated adjusted odds ratios for age, vaccination, symptoms at diagnosis, PCR cycle-threshold (Ct), occupation, exposure setting, and viral variant based on specimen date.
RESULTS: Among 15,300 community-acquired cases, offspring counts followed a negative binomial distribution(κ = 0.36). Most cases generated ≤6 secondaries, whereas 164 cases (1.1%) met the superspreader criterion and accounted for 1,571 downstream infections (11.3%). Higher odds of superspreading were observed among ages 0-19 (aOR 1.86) and 40-59 (1.84), the unvaccinated (1.64), those symptomatic at diagnosis (2.13), individuals with Ct <16.0 (2.54) or 16.0-23.9 (2.15), white-collar workers (1.68), same-facility exposures (2.39), and cases with an unknown source of infection (3.91). Superspreading odds also varied across variant-dominant periods inferred from specimen dates, although confidence intervals included unity.
CONCLUSION: SARS-CoV-2 transmission in Gangwon was highly overdispersed, with a small minority of cases responsible for a disproportionate share of spread. Targeted vaccination, rapid isolation of symptomatic or low-Ct index cases, and strengthened controls in high-risk workplaces and shared facilities may help blunt future superspreading.