The Journal of infectious diseases · 2013
Mannose-binding lectin and susceptibility to schistosomiasis.
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Antony Justin S, Ojurongbe Olusola, van Tong Hoang, Ouf Eman Abou, Engleitner Thomas, Akindele Akeem A, Sina-Agbaje Olawumi R, Adeyeba Adegboyega O, Kremsner Peter G, Velavan Thirumalaisamy P
Аннотация
BACKGROUND: Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.
METHODS: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.
RESULTS: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
CONCLUSIONS: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
METHODS: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.
RESULTS: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
CONCLUSIONS: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.