Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2024
Chemical Peels for Melasma: A Systematic Review.
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Sarkar Rashmi, Lakhani Ridhima
Аннотация
BACKGROUND: Melasma is a common chronic, relapsing pigmentary disorder that causes psychological impact. Chemical peels are a well-known therapeutic modality used for accelerating the treatment of melasma.
OBJECTIVE: To review the published evidence on the efficacy and safety of chemical peels in the treatment of melasma.
METHODS: A systematic review was done. A meta-analysis could not be done due to the heterogeneity of data.
RESULT: The authors conducted a PubMed search and included prospective case series of more than 10 cases and randomized controlled trials (RCTs) that have studied the safety and/or efficacy of chemical peel in melasma. Out of 24 studies, 9 were clinical/comparative trials and 15 were RCTs. The total sample size was 1,075. The duration of the study varied from 8 to 36 weeks. Only 8 studies were split face. All studies used self-assessment, physician global assessment, and Melasma Area and Severity Index (MASI) for quantifying the results. Glycolic acid was found to be the most safe and effective in melasma.
CONCLUSION: Chemical peels were found to be safe and effective in the management of melasma.
OBJECTIVE: To review the published evidence on the efficacy and safety of chemical peels in the treatment of melasma.
METHODS: A systematic review was done. A meta-analysis could not be done due to the heterogeneity of data.
RESULT: The authors conducted a PubMed search and included prospective case series of more than 10 cases and randomized controlled trials (RCTs) that have studied the safety and/or efficacy of chemical peel in melasma. Out of 24 studies, 9 were clinical/comparative trials and 15 were RCTs. The total sample size was 1,075. The duration of the study varied from 8 to 36 weeks. Only 8 studies were split face. All studies used self-assessment, physician global assessment, and Melasma Area and Severity Index (MASI) for quantifying the results. Glycolic acid was found to be the most safe and effective in melasma.
CONCLUSION: Chemical peels were found to be safe and effective in the management of melasma.