[Tuberculosis of the lungs complicated by opisthorchiasis under conditions of the extreme north].

Two hundred and sixty patients with pulmonary tuberculosis, residents of the North were subjected to multidisciplinary clinico-laboratory examination. The main group included 173 patients with tuberculosis complicated by opisthorchiasis. It was shown that the patients with the mixed pathology were characterized by more pronounced clinical signs of tuberculosis, more frequent disorders in the functions of the liver and pancreas and lower immunologic reactivity as compared to the patients not affected by opisthorchiasis. In the patients of the major group, activity of the alpha 1-proteinase inhibitor (alpha 1-PI) was more frequently higher and, among them, carriers of two markers i.e. Hp 2-2 and Gc 1-1 were more frequent. Factor analysis by the main components revealed that influence of helminthic invasion on biochemical and immunological reactivity of the patients with pulmonary tuberculosis was first of all brought about through the level of the serum alpha 1-PI and antiphosphatide hemagglutinins.