Impact of Elevated Serum Triglycerides on Children with Acute Recurrent or Chronic Pancreatitis from INSPPIRE-2.
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Sellers Zachary M, Giefer Matthew J, Wang Fuchenchu, Cress Gretchen A, Abu-El-Haija Maisam A, Chugh Ankur, Cohen Reuven Z, Downs Elissa M, Fishman Douglas S, Freeman A Jay, Gariepy Cheryl E, Gonska Tanja Y, Grover Amit S, Lindblad Doug, Liu Quin Y, Maqbool Asim, Mark Jacob A, McFerron Brian A, Mehta Megha S, Morinville Veronique D, Ng Kenneth, Noel Robert A, Ooi Chee Y, Perito Emily R, Phadke Madhura Y, Ruan Wenly, Schwarzenberg Sarah Jane, Troendle David M, Wilschanski Michael, Zheng Yuhua, Yuan Ying, Lowe Mark E, Uc Aliye, Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
Аннотация
STUDY DESIGN: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.7 mmol/L), any HTG (≥150 mg/dL; ≥1.7 mmol/L), mild-moderate HTG (150-499 mg/dL; 1.7-5.6 mmol/L), moderate HTG (500-999 mg/dL; 5.6-11.3 mmol/L), and severe HTG groups (≥1000 mg/dL; ≥11.3 mmol/L), based on highest serum triglyceride value. Laboratory, imaging, pancreatitis and hospital events, complications, and quality of life data were analyzed.
RESULTS: In children with acute recurrent or CP and HTG, there was no increase in the number of pancreatitis attacks per person-years, nor an increase in CP prevalence. However, HTG severity was associated with increased pancreatic inflammation, pancreatic cysts, pain, hospital days, number of hospitalizations, intensive care, and missed school days.
CONCLUSIONS: Mild-moderate HTG in children with acute recurrent or CP was not associated with increased pancreatitis frequency, nor increased development of CP, but was associated with increased pancreatitis complications and disease burden. As a treatable condition, treatment of mild-moderate HTG may be considered to reduce pancreatitis-associated complications and medical burden in children with acute recurrent or CP.