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DOI 10.1038/s41467-019-13544-0

Медицинская библиотека · Nature communications · 2019

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.

Hübel Christopher, Gaspar Héléna A, Coleman Jonathan R I, Hanscombe Ken B, Purves Kirstin, Prokopenko Inga, Graff Mariaelisa, Ngwa Julius S, Workalemahu Tsegaselassie, ADHD Working Group of the Psychiatric Genomics Consortium, Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC), Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, International Headache Genetics Consortium, O'Reilly Paul F, Bulik Cynthia M, Breen Gerome

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

Для цитирования: Hübel Christopher, Gaspar Héléna A, Coleman Jonathan R I, Hanscombe Ken B, Purves Kirstin, Prokopenko Inga, Graff Mariaelisa, Ngwa Julius S, Workalemahu Tsegaselassie, ADHD Working Group of the Psychiatric Genomics Consortium, Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC), Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, International Headache Genetics Consortium, O'Reilly Paul F, Bulik Cynthia M, Breen Gerome. Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.. Nature communications. 2019. DOI: 10.1038/s41467-019-13544-0.

Предметные рубрики MeSH

Age FactorsBlood GlucoseBody CompositionComorbidityEducational StatusFemaleGenetic VariationGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedMultifactorial InheritanceOverweightPhenotypePhysical FitnessRisk FactorsSex Factors
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