Pronounced Disparities in Amyloidosis Cardiovascular Mortality Among Elderly Adults in the United States from 1999-2020.

Amyloidosis is a group of protein-folding disorders marked by the accumulation of amyloid fibrils, leading to significant organ dysfunction. This study investigates trends in cardiovascular mortality linked to amyloidosis in the U.S. from 1999 to 2020, using data from the CDC WONDER database. We analyzed age-adjusted mortality rates (AAMR) among older adults (older than 65 years) across various demographic, racial, and geographic categories. Findings show a concerning increase in AAMR from 1.71 in 1999 to 4.23 in 2020, with a notable acceleration after 2018 (annual percentage change of +16.30). Males consistently demonstrated higher mortality rates than females, while non-Hispanic Black individuals had nearly double the AAMR compared to other racial groups. Regional analysis revealed the highest mortality rates in the Northeast and West, contrasting with lower rates in the South despite a larger Black population in that region. These disparities highlight potential influences from socioeconomic factors, healthcare access, and diagnostic practices. The increase in amyloidosis-related mortality may reflect enhanced recognition rather than an actual rise in disease prevalence. Our results underscore the urgent need for targeted public health interventions to address these disparities and improve diagnostic and treatment strategies. Continued investigation into the underlying causes of these trends is essential for enhancing patient outcomes and managing the growing burden of amyloidosis among the aging population.