Structural Connectivity Affecting Aspiration After Stroke.

Aspiration after stroke is associated with pneumonia and mortality. In this study, we investigated brain structural connectivity associated with aspiration after unilateral supratentorial stroke. Patients on oral feeding after stroke were divided into liquid aspiration (22 patients) and normal (18 patients) groups based on videofluoroscopic swallowing studies. Voxel-based lesion-symptom mapping and voxel-wise group comparison of fractional anisotropy, mode of anisotropy, and mean diffusivity maps were conducted. Voxel-based lesion-symptom mapping revealed no significant lesion differences between groups. The aspiration group showed significantly increased fractional anisotropy and mode of anisotropy in the anterior limb and the genu of the internal capsule in the right hemisphere. In contrast, the normal group showed significantly increased mean diffusivity, mainly in the superior longitudinal fasciculus in the right hemisphere (P < 0.05). Degeneration of the internal capsule in the right hemisphere was found to affect aspiration after stroke.