Head & neck · 2011
Long-term results of 28 esthesioneuroblastomas managed over 35 years.
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de Gabory Ludovic, Abdulkhaleq Habib Merza, Darrouzet Vincent, Bébéar Jean-Pierre, Stoll Dominique
Аннотация
BACKGROUND: The purpose of our study was to assess the long-term results in the management of patients with esthesioneuroblastoma.
METHODS: A total of 28 patients were retrospectively reviewed to analyze their clinical features, treatment outcomes, pattern of failures, and course of the disease.
RESULTS: The patients were classified as 2 patients with T1, 10 patients with T2, 10 patients with T3, and 6 patients with T4; the results of all were included in this study. Twenty-six patients underwent surgery and 23 had postoperative radiotherapy over the tumor bed, only 9 had radiotherapy over the nodes. The average follow-up was 99.11 months. Fifteen-year and 20-year disease-specific and disease-free survival rates were 88.6% to 66.4% and 59.6% to 29.8%, respectively. Six patients had recurrences and 60% of them occurred more than 10 years after treatment. In the first decade, nodal recurrences appeared earlier than local ones when patients with N0 did not undergo neck irradiation.
CONCLUSION: Surgery on patients with T presentations and adjuvant radiotherapy on T and N0 neck presentations seem to be essential to treat esthesioneuroblastoma. A follow-up for a minimum of 20 years is necessary to ensure complete cure.
METHODS: A total of 28 patients were retrospectively reviewed to analyze their clinical features, treatment outcomes, pattern of failures, and course of the disease.
RESULTS: The patients were classified as 2 patients with T1, 10 patients with T2, 10 patients with T3, and 6 patients with T4; the results of all were included in this study. Twenty-six patients underwent surgery and 23 had postoperative radiotherapy over the tumor bed, only 9 had radiotherapy over the nodes. The average follow-up was 99.11 months. Fifteen-year and 20-year disease-specific and disease-free survival rates were 88.6% to 66.4% and 59.6% to 29.8%, respectively. Six patients had recurrences and 60% of them occurred more than 10 years after treatment. In the first decade, nodal recurrences appeared earlier than local ones when patients with N0 did not undergo neck irradiation.
CONCLUSION: Surgery on patients with T presentations and adjuvant radiotherapy on T and N0 neck presentations seem to be essential to treat esthesioneuroblastoma. A follow-up for a minimum of 20 years is necessary to ensure complete cure.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overChemotherapy, AdjuvantChildCohort StudiesCombined Modality TherapyDisease-Free SurvivalEsthesioneuroblastoma, OlfactoryFemaleFollow-Up StudiesFranceHumansMaleMiddle AgedNasal CavityNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingNose NeoplasmsOtorhinolaryngologic Surgical ProceduresRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsTreatment OutcomeYoung Adult