AIDS research and therapy · 2025
HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana.
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Afrane Adwoa K A, Novitsky Vlad, Hague Joel, Sagoe Kwamena, Alhassan Yakubu, Dame Joycelyn Assimeng, Martyn-Dickens Charles, Lartey Margaret, Goka Bamenla, Torpey Kwasi, Kantor Rami, Kwara Awewura
Аннотация
HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.