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Войти в исследования Pediatric surgery international · 2026
Risk factors for recurrence following surgical treatment of pediatric hepatic hydatid disease.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Zouari Mohamed, Belhajmansour Manel, Hbaieb Manar, Laadhar Mahmoud, Issaoui Asma, Jarboui Oumaima, Dhaou Mahdi Ben, Mhiri Riadh
Аннотация
BACKGROUND: Postoperative recurrence remains a major challenge following surgical treatment of pediatric hepatic hydatid disease, particularly in endemic regions. The aim of this study was to identify predictors of postoperative recurrence in children undergoing surgery for hepatic hydatid disease.
METHODS: This retrospective observational cohort study included consecutive children who underwent surgical treatment for hepatic hydatid disease between 1 January 2010 and 31 December 2024. Postoperative recurrence was defined as the appearance of new hydatid cysts in the liver or abdominal cavity during follow-up after an initial disease-free period.
RESULTS: A total of 115 children were included, with a median age of 8 years and a nearly equal sex distribution. Postoperative recurrence occurred in 21 patients (18.3%) after a mean interval of 3.1 ± 1 years. Recurrence was hepatic, intraperitoneal, or combined. In univariate analysis, preoperative fever, elevated eosinophil count, prolonged operative duration, and omentoplasty were associated with recurrence. In multivariate analysis, two factors emerged as independent predictors: peripheral blood eosinophil count > 1 × 10⁹/L (OR 11.94, 95% CI 2.86-49.83; p = 0.001) and operative duration > 150 min (OR 7.29, 95% CI 1.66-31.96; p = 0.008).
CONCLUSION: Recurrence after pediatric hepatic hydatid surgery remains frequent. Beyond operative duration, eosinophilia emerges as a novel and independent predictor of recurrence, suggesting a potential role for biological markers in perioperative risk stratification and long-term follow-up.
METHODS: This retrospective observational cohort study included consecutive children who underwent surgical treatment for hepatic hydatid disease between 1 January 2010 and 31 December 2024. Postoperative recurrence was defined as the appearance of new hydatid cysts in the liver or abdominal cavity during follow-up after an initial disease-free period.
RESULTS: A total of 115 children were included, with a median age of 8 years and a nearly equal sex distribution. Postoperative recurrence occurred in 21 patients (18.3%) after a mean interval of 3.1 ± 1 years. Recurrence was hepatic, intraperitoneal, or combined. In univariate analysis, preoperative fever, elevated eosinophil count, prolonged operative duration, and omentoplasty were associated with recurrence. In multivariate analysis, two factors emerged as independent predictors: peripheral blood eosinophil count > 1 × 10⁹/L (OR 11.94, 95% CI 2.86-49.83; p = 0.001) and operative duration > 150 min (OR 7.29, 95% CI 1.66-31.96; p = 0.008).
CONCLUSION: Recurrence after pediatric hepatic hydatid surgery remains frequent. Beyond operative duration, eosinophilia emerges as a novel and independent predictor of recurrence, suggesting a potential role for biological markers in perioperative risk stratification and long-term follow-up.