eLife · 2019
Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Haraguchi Shogo, Kamata Masaki, Tokita Takuma, Tashiro Kei-Ichiro, Sato Miku, Nozaki Mitsuki, Okamoto-Katsuyama Mayumi, Shimizu Isao, Han Guofeng, Chowdhury Vishwajit Sur, Lei Xiao-Feng, Miyazaki Takuro, Kim-Kaneyama Joo-Ri, Nakamachi Tomoya, Matsuda Kouhei, Ohtaki Hirokazu, Tokumoto Toshinobu, Tachibana Tetsuya, Miyazaki Akira, Tsutsui Kazuyoshi
Аннотация
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks.