Медицинская библиотека · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2002

[Analyses of genetic model of psoriasis vulgaris].

Zhang Xuejun, Wang Hongyan, Chen Shanyu, Wang Fuxi, Liu Taofeng, Wang Zaixing, Li Ming, Yang Sen

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Аннотация

OBJECTIVE

To explore the possible genetic model of psoriasis vulgaris.

METHODS

The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.

RESULTS

It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.

CONCLUSION

The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.

Для цитирования: Zhang Xuejun, Wang Hongyan, Chen Shanyu, Wang Fuxi, Liu Taofeng, Wang Zaixing, Li Ming, Yang Sen. [Analyses of genetic model of psoriasis vulgaris].. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 2002.

Предметные рубрики MeSH

Adolescent Adult Aged Child Child, Preschool Data Interpretation, Statistical Family Health Female Humans Male Middle Aged Models, Genetic Psoriasis

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