Parkinsonism & related disorders · 2025
The Progressive Supranuclear Palsy Clinical Deficits Scale accurately reflects functional as well as patient- and caregiver-reported outcomes.
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Lim Yi Zhe, Ngim Su Juen, Fernandiz Jeremy Christopher, Dy Closas Alfand Marl F, Toh Tzi Shin, Khairul Anuar Anis Nadhirah, Chang Emily Siew Wen, Cheok Johnny Jun Wei, Tay Yi Wen, Ding Hans Xing, Schee Jie Ping, Chu Grace Sze Ern, Lit Lei Cheng, Tan Ai Huey, Lim Shen-Yang
Аннотация
BACKGROUND: Progressive supranuclear palsy (PSP) is a common atypical parkinsonian disorder, but a significant gap in clinical and research practice has been the unavailability until very recently of a brief but accurate scale to rate its clinical severity. The 7-item PSP Clinical Deficits Scale (PSP-CDS) offers an efficient method to evaluate PSP clinical severity and can be administered relatively rapidly. However, further validation of this new tool is needed.
METHODS: Patients with PSP (n = 110; 55.5 % with Richardson syndrome [PSP-RS]) were consecutively recruited at a quaternary centre in Malaysia. We examined the correlations between the PSP-CDS and measures of patients' functional status, using the Barthel Index (which is generic, brief, and clinician rated) and the Cortical Basal ganglia Functional Scale (CBFS; which is disease-specific, more comprehensive, and patient/caregiver reported).
RESULTS: There were strong correlations between the PSP-CDS vs. the Barthel Index (rs = -0.81) and the CBFS (rs = 0.64) (both P < 0.001). In a post hoc analysis of individual items of the PSP-CDS and Barthel Index and CBFS, significant (and also mostly strong) correlations were observed, in the motor as well as non-motor domains.
CONCLUSIONS: The strong correlations between PSP disease severity as measured by the PSP-CDS vs. generic and disease-specific measures of functional status, rated by clinicians and patients and caregivers, provide further support for the PSP-CDS as a valid and efficient instrument. More widespread use of such tools can help to address the global gap of inadequate phenotyping of patients in routine clinical and research practice.
METHODS: Patients with PSP (n = 110; 55.5 % with Richardson syndrome [PSP-RS]) were consecutively recruited at a quaternary centre in Malaysia. We examined the correlations between the PSP-CDS and measures of patients' functional status, using the Barthel Index (which is generic, brief, and clinician rated) and the Cortical Basal ganglia Functional Scale (CBFS; which is disease-specific, more comprehensive, and patient/caregiver reported).
RESULTS: There were strong correlations between the PSP-CDS vs. the Barthel Index (rs = -0.81) and the CBFS (rs = 0.64) (both P < 0.001). In a post hoc analysis of individual items of the PSP-CDS and Barthel Index and CBFS, significant (and also mostly strong) correlations were observed, in the motor as well as non-motor domains.
CONCLUSIONS: The strong correlations between PSP disease severity as measured by the PSP-CDS vs. generic and disease-specific measures of functional status, rated by clinicians and patients and caregivers, provide further support for the PSP-CDS as a valid and efficient instrument. More widespread use of such tools can help to address the global gap of inadequate phenotyping of patients in routine clinical and research practice.