Acta ophthalmologica Scandinavica · 2000
Lacrimal canalicular stenosis associated with systemic 5-fluorouacil therapy.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Prasad S, Kamath G G, Phillips R P
Аннотация
PURPOSE: Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation of therapy. Permanent stenosis of lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication of 5-fluorouracil therapy.
METHODS: Report of two cases and review of literature.
RESULTS: Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy.
CONCLUSION: It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.
METHODS: Report of two cases and review of literature.
RESULTS: Severe stenosis of puncta and canaliculi may be associated with prolonged systemic 5-fluorouracil therapy.
CONCLUSION: It is important for both the oncologist and ophthalmologist to be aware of the potential ocular toxicity of 5-fluorouracil. Surgical management to relieve the epiphora is often challenging, and early intervention may be beneficial.