Медицинская библиотека · Future oncology (London, England) · 2024

An observational study of once-weekly carfilzomib in patients with multiple myeloma in Japan (Weekly-CAR study).

Abe Yu, Kubonishi Shiro, Ri Masaki, Iino Masaki, Sunami Kazutaka, Ito Tomoki, Fukaya Masafumi, Kitano Toshiyuki, Ikeda Sho, Ota Shuichi, Kuroi Taiga, Iriyama Noriyoshi, Jo Tatsuro, Adachi Masaaki, Akahane Daigo, Kai Tatsuyuki, Kohara Yoichi, Kadowaki Norimitsu, Katayama Teruaki

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Аннотация

Background

The ARROW study demonstrated that once-weekly carfilzomib and dexamethasone (wKd) therapy significantly prolonged progression-free survival compared with twice-weekly carfilzomib and dexamethasone therapy in relapsed or refractory multiple myeloma patients. Aim: To describe the treatment patterns, effectiveness and safety of wKd therapy in real-world settings in Japan.

Methods

We investigated data from the medical records of 126 Japanese patients with relapsed or refractory multiple myeloma.

Results

The overall response rate was 66.3%. The median progression-free survival was 9.5 months. The incidence of treatment-emergent adverse events of any grade and grade ≥3 were 45.8 and 20.8%, respectively.

Conclusion

There were no new or unexpected safety signals in this study. This study demonstrated the effectiveness and safety profiles of wKd therapy in Japan.

Для цитирования: Abe Yu, Kubonishi Shiro, Ri Masaki, Iino Masaki, Sunami Kazutaka, Ito Tomoki, Fukaya Masafumi, Kitano Toshiyuki, Ikeda Sho, Ota Shuichi, Kuroi Taiga, Iriyama Noriyoshi, Jo Tatsuro, Adachi Masaaki, Akahane Daigo, Kai Tatsuyuki, Kohara Yoichi, Kadowaki Norimitsu, Katayama Teruaki. An observational study of once-weekly carfilzomib in patients with multiple myeloma in Japan (Weekly-CAR study).. Future oncology (London, England). 2024. DOI: 10.2217/fon-2023-0834.

Предметные рубрики MeSH

Humans Multiple Myeloma Oligopeptides Male Female Aged Middle Aged Japan Antineoplastic Combined Chemotherapy Protocols Dexamethasone Aged, 80 and over Drug Administration Schedule Adult Progression-Free Survival Treatment Outcome Neoplasm Recurrence, Local

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