Journal of the American Academy of Dermatology · 1998
Mucocutaneous manifestations of the hyper-IgM immunodeficiency syndrome.
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Chang M W, Romero R, Scholl P R, Paller A S
Аннотация
BACKGROUND: The recurrent pyogenic infections of patients with hyper-IgM syndrome are controlled by intravenous gamma globulin administration, but patients may suffer from early-onset oral ulcerations and warts.
OBJECTIVE: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it.
METHODS: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed.
RESULTS: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. Warts tend to be widespread and resistant to traditional therapy.
CONCLUSION: Physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts.
OBJECTIVE: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it.
METHODS: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed.
RESULTS: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. Warts tend to be widespread and resistant to traditional therapy.
CONCLUSION: Physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts.