Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
[Immune dynamics and predictive factors for chronic graft versus host disease following haploidentical hematopoietic stem cell transplantation in children].
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Tang Ran-Ran, Zhao Yu-Yang, Li Yue, Zhou Xiao-Hui, Chen Shi-Yang, Duan Qiu-Yue, Peng Dong, Kuang Ya-Xian, Luo Li-Ping, Liu Si-Xi, Fu Xiao-Ying
Аннотация
OBJECTIVES: To investigate the immunological characteristics and predictive factors of chronic graft-versus-host disease (cGVHD) in children after haploidentical allogeneic hematopoietic stem cell transplantation (Haplo-HSCT) to provide a basis for early intervention.
METHODS: A retrospective analysis was conducted on clinical and laboratory data of 64 children undergoing Haplo-HSCT. Peripheral blood lymphocyte subsets, immunoglobulins, and key components of the complement system were measured. Univariable and multivariable logistic regression analyses were used to identify predictors.
RESULTS: The percentage of helper/inducer T lymphocytes and complement C3 levels were significantly higher in the cGVHD group (n=37) compared to the non-cGVHD group (n=27) (P<0.05), while the percentages of B cells and natural killer (NK) cells were significantly lower (P<0.05). Multivariate logistic regression identified the percentage of helper/inducer T lymphocytes (OR=1.144, P=0.012) and complement C3 level (OR=29.758, P=0.037) as independent predictors of cGVHD.
CONCLUSIONS: The development of cGVHD is closely associated with T-cell homeostasis imbalance, B-cell functional exhaustion, and abnormal activation of the complement system. The percentage of helper/inducer T lymphocytes and complement C3 levels may serve as potential predictive indicators for cGVHD occurrence.
METHODS: A retrospective analysis was conducted on clinical and laboratory data of 64 children undergoing Haplo-HSCT. Peripheral blood lymphocyte subsets, immunoglobulins, and key components of the complement system were measured. Univariable and multivariable logistic regression analyses were used to identify predictors.
RESULTS: The percentage of helper/inducer T lymphocytes and complement C3 levels were significantly higher in the cGVHD group (n=37) compared to the non-cGVHD group (n=27) (P<0.05), while the percentages of B cells and natural killer (NK) cells were significantly lower (P<0.05). Multivariate logistic regression identified the percentage of helper/inducer T lymphocytes (OR=1.144, P=0.012) and complement C3 level (OR=29.758, P=0.037) as independent predictors of cGVHD.
CONCLUSIONS: The development of cGVHD is closely associated with T-cell homeostasis imbalance, B-cell functional exhaustion, and abnormal activation of the complement system. The percentage of helper/inducer T lymphocytes and complement C3 levels may serve as potential predictive indicators for cGVHD occurrence.