Functional brain connectivity changes following Masterson Psychotherapy in borderline personality disorder: a pilot study.

The Masterson Psychotherapy (MP) is a therapeutic method used to manage symptoms of Borderline Personality Disorder (BPD). This pilot study aimed to investigate the effects of MP on brain connectivity in individuals with BPD using resting-state fMRI. We collected resting-state fMRI data from 10 individuals with BPD before and after 20 MP sessions to examine changes in brain connectivity. Pre-therapy data from these individuals were also compared to data from 10 healthy controls. Results showed reduced hippocampal connectivity in individuals with BPD compared to controls, which significantly improved following MP. Notably, improvements in hippocampal connectivity were correlated with clinical reductions in BPD symptoms. This preliminary study suggests that the therapeutic benefits of MP in BPD may be associated with enhanced hippocampal connectivity.