Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine).
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Adamo Daniela, Calabria Elena, Coppola Noemi, Lo Muzio Lorenzo, Giuliani Michele, Azzi Lorenzo, Maurino Vittorio, Colella Giuseppe, Rauso Raffaele, Montebugnoli Lucio, Gissi Davide Bartolomeo, Gabriele Mario, Nisi Marco, Sardella Andrea, Lodi Giovanni, Varoni Elena Maria, Giudice Amerigo, Antonelli Alessandro, Cabras Marco, Gambino Alessio, Vescovi Paolo, Majorana Alessandra, Bardellini Elena, Campisi Giuseppina, Panzarella Vera, Spadari Francesco, Marino Sonia, Pentenero Monica, Sutera Samuele, Biasotto Matteo, Gobbo Margherita, Guarda Nardini Luca, Romeo Umberto, Tenore Gianluca, Serpico Rosario, Lucchese Alberta, Lajolo Carlo, Rupe Cosimo, Aria Massimo, Gnasso Agostino, Mignogna Michele Davide, SIPMO (Italian Society of Oral Pathology, Medicine)
Аннотация
METHODS: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered.
RESULTS: Oral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub-items (p-values < 0.001**). Moreover, OLPs had higher scores in the HAM-D, HAM-A, NRS, and T-PRI (p-values < 0.001**). No differences in the PSQI sub-items' scores were found between the K-OLPs and nK-OLPs, although nK-OLPs suffered from higher levels of anxiety, depression, and pain (p-values: HAM-A, 0.007**, HAM-D, 0.009**, NRS, <0.001**, T-PRI, <0.001**). The female gender, anxiety, depression (p-value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p-value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K-OLPs and nK-OLPs, respectively. The PSQI's validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI.
CONCLUSIONS: The OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.