Cell · 2023

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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Rosain Jérémie, Neehus Anna-Lena, Manry Jérémy, Yang Rui, Le Pen Jérémie, Daher Wassim, Liu Zhiyong, Chan Yi-Hao, Tahuil Natalia, Türel Özden, Bourgey Mathieu, Ogishi Masato, Doisne Jean-Marc, Izquierdo Helena M, Shirasaki Takayoshi, Le Voyer Tom, Guérin Antoine, Bastard Paul, Moncada-Vélez Marcela, Han Ji Eun, Khan Taushif, Rapaport Franck, Hong Seon-Hui, Cheung Andrew, Haake Kathrin, Mindt Barbara C, Pérez Laura, Philippot Quentin, Lee Danyel, Zhang Peng, Rinchai Darawan, Al Ali Fatima, Ahmad Ata Manar Mahmoud, Rahman Mahbuba, Peel Jessica N, Heissel Søren, Molina Henrik, Kendir-Demirkol Yasemin, Bailey Rasheed, Zhao Shuxiang, Bohlen Jonathan, Mancini Mathieu, Seeleuthner Yoann, Roelens Marie, Lorenzo Lazaro, Soudée Camille, Paz María Elvira Josefina, González María Laura, Jeljeli Mohamed, Soulier Jean, Romana Serge, L'Honneur Anne-Sophie, Materna Marie, Martínez-Barricarte Rubén, Pochon Mathieu, Oleaga-Quintas Carmen, Michev Alexandre, Migaud Mélanie, Lévy Romain, Alyanakian Marie-Alexandra, Rozenberg Flore, Croft Carys A, Vogt Guillaume, Emile Jean-François, Kremer Laurent, Ma Cindy S, Fritz Jörg H, Lemon Stanley M, Spaan András N, Manel Nicolas, Abel Laurent, MacDonald Margaret R, Boisson-Dupuis Stéphanie, Marr Nico, Tangye Stuart G, Di Santo James P, Zhang Qian, Zhang Shen-Ying, Rice Charles M, Béziat Vivien, Lachmann Nico, Langlais David, Casanova Jean-Laurent, Gros Philippe, Bustamante Jacinta

Аннотация

Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. These children have no history of severe viral disease, despite exposure to many viruses, including SARS-CoV-2, which is life-threatening in individuals with impaired IFN-α/β immunity. In leukocytes or fibroblasts stimulated in vitro, IRF1-dependent responses to IFN-γ are, both quantitatively and qualitatively, much stronger than those to IFN-α/β. Moreover, IRF1-deficient mononuclear phagocytes do not control mycobacteria and related pathogens normally when stimulated with IFN-γ. By contrast, IFN-α/β-dependent intrinsic immunity to nine viruses, including SARS-CoV-2, is almost normal in IRF1-deficient fibroblasts. Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity.

Предметные рубрики MeSH

Child Humans Interferon-gamma COVID-19 SARS-CoV-2 Interferon-alpha Mycobacterium Interferon Regulatory Factor-1

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.

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Аннотация

Предметные рубрики MeSH