Long-term disease progression in pediatric acute recurrent and chronic pancreatitis: A report from INSPPIRE.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Downs Elissa M, Perito Emily R, Wang Fuchenchu, Cress Gretchen A, Abu-El-Haija Maisam, Chugh Ankur, Cohen Reuven Zev, Fishman Douglas S, Freeman A Jay, Gariepy Cheryl E, Giefer Matthew J, Gonska Tanja Y, Grover Amit S, Husain Sohail Z, Lindblad Douglas, Liu Quin Y, Maqbool Asim, Mark Jacob A, McFerron Brian A, Mehta Megha S, Morinville Veronique D, Ng Kenneth, Noel Robert Adam, Ooi Chee Y, Troendle David M, Wilschanski Michael, Zheng Yuhua, Yuan Ying, Lowe Mark E, Uc Aliye, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE)
Аннотация
METHODS: INSPPIRE subjects were categorized as persistent ARP (pARP = remained ARP through last follow-up), incident CP (iCP = ARP at enrollment, developed CP), or prevalent CP (pCP = CP at enrollment). Time-to-sequelae and risk factors were analyzed.
RESULTS: Of 626 total children, 384 (61%) were ARP at baseline; of these, 81 (21.1%) were iCP at follow-up. iCP were more likely to have PRSS1 mutations, obstructive risk factors, and more acute pancreatitis episodes (AP) vs. pARP, but didn't differ in age at first AP. Exocrine pancreatic insufficiency (EPI) developed in 24% during follow-up, 10% of pARP, 32% of iCP. In all CP, 50% had EPI by 17.7yrs, median 10yrs after first AP. Diabetes mellitus (DM) developed in 8% during follow-up, 6% of pARP, 5% of iCP. In all CP, median event-free survival from birth and after first AP was not reached.
CONCLUSIONS: Prospective follow-up of children with ARP revealed nearly 1 in 5 progressed to CP, with a subset developing irreversible sequelae, and highlighted risk factors associated with progression including genetics, obstructive disease, and episode frequency.