The Role of Nasal Drug Delivery in Migraine Management and Brain-Targeted Therapy: Insights From Taiwan.

This letter responds to a recent review on nasal drug delivery systems for brain-targeted therapy. Drawing on first hand experiences as a psychiatrist and migraine patient in Taiwan, the response discusses the practical benefits and challenges of using nasal formulations, such as sumatriptan nasal spray, during ongoing drug shortages. While these formulations offer rapid onset of action, issues related to taste and odor can limit adherence. The letter highlights the potential of advanced technologies like nanocarriers to improve nasal drug delivery and emphasizes the need for patient-centered designs. The correspondence concludes with recommendations for diversifying drug delivery approaches to enhance efficacy and accessibility.