Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2021
Single-nucleotide polymorphism in chronic rhinosinusitis: A systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Antonino Maniaci, Nicolò Musso, Jerome Renee Lechien, Federico Merlino, Chiara Viglianisi, Stefano Stracquadanio, Maria Santagati, Salvatore Cocuzza, Antonio Bonanno, Calvo-Henriquez Christian, Stefania Stefani, La Mantia Ignazio
Аннотация
OBJECTIVES: We performed a systematic review on single-nucleotide polymorphisms and risk-related chronic rhinosinusitis.
DESIGN AND SETTING: A comprehensive review of the last 20 years' English language literature regarding chronic rhinosinusitis and single-nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps.
RESULTS: We found 12 papers with 9127 patients, of which 2739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were atopy in 4555 (49.9%), asthma in 4594 (50.33%), Samter Triad in 448 (4.9%) and eosinophilia in 391 subjects (4.28%).
CONCLUSION: Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single-nucleotide polymorphisms.
DESIGN AND SETTING: A comprehensive review of the last 20 years' English language literature regarding chronic rhinosinusitis and single-nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps.
RESULTS: We found 12 papers with 9127 patients, of which 2739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were atopy in 4555 (49.9%), asthma in 4594 (50.33%), Samter Triad in 448 (4.9%) and eosinophilia in 391 subjects (4.28%).
CONCLUSION: Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single-nucleotide polymorphisms.